The lack of available vaccines against African swine fever virus ASFV means that the evaluation of new immunization strategies is required. Here we show that fusion of the extracellular domain of the ASFV Hemagglutinin sHA to p54 and p30, two immunodominant structural viral antigens, exponentially improved both the humoral and the cellular responses induced in pigs after DNA immunization. Our results confirm the relevance of T-cell responses in protection against ASF and open new expectations for the future development of more efficient recombinant vaccines against this disease. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. African Swine Fever ASF is a fatal hemorrhagic disease of domestic pigs caused by African Swine Fever Virus ASFV , the only member of the family Asfarviridae , a large enveloped virus that contains a linear double-stranded DNA of — kbp encoding more than proteins, many of them involved in virus-host interactions . The fact that the disease is endemic in many Sub-Saharan Africa countries and Sardinia, makes this disease a threat for disease-free countries, as has been demonstrated with the recent outbreaks declared in Georgia, Russia, Armenia, and Iran  — . Unfortunately, there is no vaccine available for ASFV.
Enter your mobile number or email address below and we'll send you a link to download the free Kindle App. Then you can start reading Kindle books on your smartphone, tablet, or computer - no Kindle device required. To get the free app, enter your mobile phone number. Micul tratat pentru parjoala ne invata care este diferenta intre chiftea si parjoala, Uha, celebra ciorba de peste ruseasca, ne este servita impreuna cu reportajul in versuri al unei calatorii cu peripetii, prilejuita de o prezentare de filme in Uniunea Sovietica, Placinta de pipote ne starneste pofta si curiozitate, iar la final, o surpriza: trei retete trimise intr-o scrisoare de catre Aglae Drogli, sora cea mare a lui Mihai Eminescu, Harietei, sora cea mica. Read more Read less. Previous page. Humanitas Multimedia. Publication date.
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